Debra Messing and husband, Daniel Zelman, have parted ways after 10-years, just as Messing’s career is rebounding with a new television series backed by Steven Spielberg.

Messing, 43, had a hugely successful run on television in the hit sit-com “Will & Grace,” which ran for eight seasons through 2006.

After graduating summa cum laude from Brandeis University with a bachelor’s degree in theater arts, Messing met Zelman while both were graduate students at New York University.

Messing was one of only 15 students who were accepted into the Tisch School of the Arts and earned a Master’s Degree in Fine Arts after three years.

Over the last couple of years, though, her television career has been a non-starter.

She reprised her role as Molly Kagan for a television series based on “The Starter Wife,” a five-part miniseries. It was cancelled after 10 episodes.

She also starred in the ABC comedy pilot “Wright vs. Wrong,” slated for the 2010-2011 primetime season, but ABC passed on the pilot.

Messing and Zelman, an actor and producer, dated for eight years before getting married in 2000. She had a child, Roman Walker, with Zelman in 2004.

The couple actually separated earlier this year, but the split was only confirmed by People today (Dec. 20).

The pair “privately separated earlier this year after a 10 year marriage,” Messing’s rep said.

“The decision was mutual, and they remain supportive of one another and committed to raising their son as a family,” the rep added.

In her new series, Messing and Christian Borle play writers, while American Idol runner-up Katherine McPhee is the aspiring actress

The hour-long series is obviously inspired by the success of Fox’s musical series “Glee,” which includes staged dance productions much like a theater musical.

“When you have a really good show, there’s a sense of excitement,” says Anjelica Houston in a behind-the-scenes video.

Houston plays a Broadway producer of a fictional musical about Marilyn Monroe.

The show will feature lots of backstage drama and personal conflict as egos clash over the creation of the show.

It premieres Feb. 6 at 8pm, Eastern. Check out the extended video below.